The school, which serves grades 9 through 12, is a part of the Mesquite Independent School District. West Mesquite opened as a middle school in 1976, housing 7th, 8th, and 9th grades. The first graduating class received diplomas in 1984!
The school is located near the Mesquite Championship Rodeo at the Mesquite Arena, and was actually built on land once owned by the Rodeo. There was once a pond that horses drank from. If it were there today, it would cover the water fountain, and much of the north end of the Memorial Stadium.
Also located near campus is the the Mesquite Tower which broadcasts the school district's own radio station, KEOM.